期刊
BIO-PROTOCOL
卷 11, 期 2, 页码 -出版社
BIO-PROTOCOL
DOI: 10.21769/BioProtoc.3895
关键词
Bioinorganic Chemistry; Toxicity; Artemia salina; Larvae mortality of brine shrimp
类别
资金
- European Union
- Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH-CREATEINNOVATE [T1EDK-02990]
- State Scholarships Foundation (IK.) through the Operational Programme Human Resources Development, Education and Lifelong Learning [2019-050-0503-17816, MIS-5033021]
- European Union (European Social Fund-ESF)
- COST Action [CA17104]
- Oncology Department of Novartis Hellas S.A.C.I. [82819]
The in vivo toxicity of new metallodrugs can be evaluated using the brine shrimp assay, which is low cost, safe, and does not require feeding during the assay, while only a small amount of the tested agent is needed.
The in vivo toxicity of new metallodrugs either as Small Bioactive Molecules (SBAMs) or Conjugates of Metals with Drugs (CoMeDs) or their hydrogels such as with hydroxyethyl-methacrylate (HEMA) (pHEMA@SBAMs or pHEMA@CoMeDs) are evaluated by the brine shrimp assay. Thus individuals of Artemia salina larvae are incubated in saline solutions with SBAMs, CoMeDs, pHEMA@ SBAMs or pHEMA@ CoMeDs or without for 24 h. The toxicity is then determined in terms of the mortality rate of brine shrimp larvae. Brine shrimp assay is a low cost, safe, no required feeding during the assay, while it requiring only a small amount of the tested agent.
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