期刊
LEARNING & MEMORY
卷 28, 期 1, 页码 12-17出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.052373.120
关键词
-
资金
- Miami University College of Arts and Sciences and Department of Psychology
This study found that traumatic events in infancy have lasting effects on fear learning and extinction learning in adult mice, but have limited impact on other behaviors.
Early life stress (ELS) experiences can cause changes in cognitive and affective functioning. This study examined the persistent effects of a single traumatic event in infancy on several adult behavioral outcomes in male and female C57BL/6J mice. Mice received 15 footshocks in infancy and were tested for stress-enhanced fear learning, extinction learning, discrimination and reversal learning, and novel object recognition. Infant trauma potentiated fear learning in adulthood and produced resistance to extinction but did not influence other behaviors, suggesting restricted effects of infant trauma on behaviors reliant on cortico-amygdala circuitry.
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