期刊
NPJ SCIENCE OF FOOD
卷 5, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41538-021-00084-5
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资金
- Japan Society for the Promotion of Science [15H02894]
- Cross-Ministerial Strategic Innovation Promotion Program (SIP)
- Japan Agency for Medical Research and Development [16dk0207021h0001]
- Grants-in-Aid for Scientific Research [15H02894] Funding Source: KAKEN
Rosmarinic acid (RA) inhibits the accumulation of Aβ and phosphorylated tau, improves cognitive function, and suppresses hippocampal inflammation in the 3xTg-AD mouse model. Additionally, RA exerts anti-inflammatory effects by downregulating the JNK signaling pathway, suggesting a potential mechanism for inhibiting the progression of pathology and cognitive deficits.
Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is a candidate of preventive ingredients against Alzheimer's disease (AD) as it potently suppresses the aggregation of amyloid beta (A beta); however, the effect of RA on tau phosphorylation and cognitive dysfunction remains unclear. The present study revealed that RA intake inhibited the pathological hallmarks of AD, including A beta and phosphorylated tau accumulation, and improved cognitive function in the 3 x Tg-AD mouse model. Additionally, RA intake suppressed hippocampal inflammation and led to the downregulation of the JNK signaling pathway that induces tau phosphorylation. Feeding with RA exerted an anti-inflammatory effect not only in the central nervous system but also in the periphery. Downregulation of the JNK signaling pathway in hippocampus may be a potential mechanism underlying the inhibition of progression of pathology and cognitive deficit by RA feeding.
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