期刊
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
卷 15, 期 2, 页码 279-286出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1932296819886917
关键词
continuous glucose monitoring; critically ill; glucose control; glucose variability; hyperglycemia; hypoglycemia
资金
- OptiScan Biomedical
The study showed that using OptiScanner (OS) 5000 for blood glucose monitoring in critically ill patients significantly reduced episodes of hypoglycemia, hyperglycemia, severe hyperglycemia, and glucose variability, indicating improved quality and safety of glucose control.
Background: The use of near-continuous blood glucose (BG) monitoring has the potential to improve glycemic control in critically ill patients. The MANAGE IDE trial evaluated the performance of the OptiScanner (OS) 5000 in a multicenter cohort of 200 critically ill patients. Methods: An Independent Group reviewed the BG run charts of all 200 patients and voted whether unblinded use of the OS, with alarms set at 90 and 130 to 150mg/dL to alert the clinical team to impending hypoglycemia and hyperglycemia, respectively, would have eliminated episodes of dysglycemia: hypoglycemia, defined as a single BG <70mg/dL; hyperglycemia, defined as >4hours of BG >150mg/dL; severe hyperglycemia, defined as >4hours of BG >200mg/dL and increased glucose variability (GV), defined as coefficient of variation (CV) >20%. Results: At least one episode of dysglycemia occurred in 103 (51.5%) of the patients, including 6 (3.0%) with hypoglycemia, 83 (41.5%) with hyperglycemia, 18 (9.0%) with severe hyperglycemia, and 40 (20.0%) with increased GV. Unblinded use of the OS with appropriate alarms would likely have averted 97.1% of the episodes of dysglycemia: hypoglycemia (100.0%), hyperglycemia (96.4%), severe hyperglycemia (100.0%), and increased GV (97.5%). Point accuracy of the OS was very similar to that of the point of care BG monitoring devices used in the trial. Conclusion: Unblinded use of the OS would have eliminated nearly every episode of dysglycemia in this cohort of critically ill patients, thereby markedly improving the quality and safety of glucose control.
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