How to Study the Sex and Gender Effect in Biomedical Research?

Men and women are different, but this difference has not been well reflected in clinical trials and preclinical studies of biomedical science. Gender medicine, which systematically analyzes research results according to sex and gender, has been emphasized to overcome this problem. On the other hand, researchers still have difficulty in applying gender medicine to their research. To perform rigorous gender medicine, using correct terms, a thorough literature review during research planning, appropriate statistical analysis and reporting, and cautious interpretation of the results are necessary. Applying gender medicine will increase the reproducibility of studies, promote discoveries, expand the study relevance, and ultimately improve patient care in both men and women. Here, this study reviewed the practical issues on applying gender medicine to both preclinical and clinical studies in the field of biomedical science. (Korean J Gastroenterol 2021;77:104-114)

Automated summary

Gender medicine aims to analyze research results systematically according to sex and gender to address the lack of reflection of gender differences in biomedical research. However, researchers still face challenges in applying gender medicine to their studies. To conduct rigorous gender medicine research, using correct terminology, conducting thorough literature reviews, appropriate statistical analysis and cautious interpretation of results are necessary.