期刊
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
卷 11, 期 4, 页码 589-599出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s40097-021-00386-w
关键词
Fe3O4; Magnetic nanoparticles; PAMAM dendrimers; TEOS; Au; Bi2O3; Medical applications; X-ray tomography
资金
- Duzce University Scientific Research Project Commission [2019.07.06.981]
The study investigated the utilization of Fe3O4@G2/Au/Bi2O3 nanocomposites for multimodal imaging applications. The physical and chemical structures of the nanocomposites were characterized using SEM, TEM, EDX, FTIR, and VSM. The results showed that the nanocomposites exhibit superparamagnetic properties suitable for MRI and magnetic hyperthermia applications, and their X-ray imaging and CT imaging properties were also confirmed.
Fe3O4 magnetic nanoparticles were produced and covered with TEOS and APTES which were known to reduce the toxic properties of nanoparticles. Nanoparticles were functionalized second-generation PAMAM dendrimers and doped with Au and Bi2O3 nanoparticles where Fe3O4@G2/Au/Bi2O3 nanocomposites were obtained for potential multimodal imaging applications. Physicals structures of the nanocomposites were characterized using SEM and TEM which illustrate that nanoparticles were in composite form. Chemical composition of nanostructures was confirmed using EDX and FTIR. Magnetic characteristics were checked using VSM. It was seen that nanoparticles have superparamagnetic properties which indicate that nanocomposites have potential to be used in MRI and magnetic hyperthermia applications. X-ray imaging properties were confirmed using X-ray imaging and CT imaging. It was confirmed that doping nanoparticles with Au and Bi2O3 nanoparticles significantly enhanced the X-ray tomography contrast enhancement properties which illustrate the theranostic properties of the nanocomposites.
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