期刊
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
卷 4, 期 2, 页码 589-612出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsptsci.0c00212
关键词
nanocarriers; chemotherapy; ultrasound; drug release
资金
- American University of Sharjah Faculty Research Grants [FRG20-L-48, eFRG18-BBR-CEN-03]
- Al-Jalila Foundation [AJF 2015555]
- Al Qasimi Foundation
- Patient's Friends Committee-Sharjah
- Biosciences and Bioengineering Research Institute [BBRI18-CEN-11]
- GCC Co-Fund Program [IRF17-003]
- Takamul program [POC00028-18]
- Technology Innovation Pioneer (TIP) Healthcare Awards
- Dana Gas Endowed Chair for Chemical Engineering
Nano-sized carriers designed for selective delivery of anticancer drugs and genes to tumors can achieve enhanced therapeutic effects by triggering the release of therapeutic drugs through stimuli. Recent research has focused on the application of various stimuli-responsive nanocarriers, showing promising prospects for cancer treatment.
The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and bioavailability. Nanocarriers are nanosized particles designed for the selectivity of anticancer drugs and gene transport to tumors. They are small enough to extravasate into solid tumors, where they slowly release their therapeutic load by passive leakage or biodegradation. Using smart nanocarriers, the rate of release of the entrapped therapeutic(s) can be increased, and greater exposure of the tumor cells to the therapeutics can be achieved when the nanocarriers are exposed to certain internally (enzymes, pH, and temperature) or externally (light, magnetic field, and ultrasound) applied stimuli that trigger the release of their load in a safe and controlled manner, spatially and temporally. This review gives a comprehensive overview of recent research findings on the different types of stimuli-responsive nanocarriers and their application in cancer treatment with a particular focus on ultrasound.
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