期刊
FUTURE VIROLOGY
卷 12, 期 11, 页码 685-707出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fvl-2017-0042
关键词
Central Africa; genital ulcer disease; HIV; male circumcision; origin of HIV; unsterile injections; West Africa
类别
资金
- Fonds voor Wetenschappelijk Onderzoek - Flanders (FWO), Belgium [G.0692.14]
- [GINOP-2.3.2-15-2016-00057]
Humans acquired retroviruses from simians, mainly through bushmeat handling. All epidemically successful HIV groups started to spread in early 20th century, contrasting with the antiquity of T-cell lymphotropic viruses, implying that novel enabling factors were involved in HIV emergence. Here we review the Parenteral Serial Transmission and the Enhanced Heterosexual Transmission hypotheses for the adaptation and early spread of HIV. Epidemic start roughly coincides in time with peak genital ulcer disease in cities, suggesting a major role for sexual transmission. Only ill-adapted and rare HIV groups emerged after approximately 1950, when injections and transfusions attained their maximal levels, suggesting that if parenteral serial transmission was necessary for HIV adaptation, it had to be complemented by sexual transmission for HIV to reach epidemic potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据