相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity
Shraddha Thakkar et al.
DRUG DISCOVERY TODAY (2020)
The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
Si Chen et al.
ARCHIVES OF TOXICOLOGY (2020)
Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme
Dimitrios Vagiannis et al.
CANCERS (2020)
Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Database
Zhi Liu et al.
CURRENT DRUG METABOLISM (2019)
Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity
Eric Uwimana et al.
TOXICOLOGICAL SCIENCES (2019)
Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes
Jakub Hofman et al.
MOLECULAR PHARMACEUTICS (2019)
Determination of the human cytochrome P450 monooxygenase catalyzing the enantioselective oxidation of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) and 2,2',3,4,4',5',6-heptachlorobiphenyl (PCB 183)
Haruna Nagayoshi et al.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2018)
The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone
Si Chen et al.
ARCHIVES OF TOXICOLOGY (2018)
DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells
Si Chen et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2018)
Human Liver Microsomes Atropselectively Metabolize 2,2 ',3,4 ',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite
Eric Uwimana et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Laia Tolosa et al.
ARCHIVES OF TOXICOLOGY (2018)
Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing
M. Jose Gomez-Lechon et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2017)
Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines
Ashley R. Maiuri et al.
TOXICOLOGICAL SCIENCES (2016)
Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity
Mengbi Yang et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
Jiekun Xuan et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer
Shalenie P. den Braver-Sewradj et al.
TOXICOLOGY IN VITRO (2016)
The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity
Qiangen Wu et al.
TOXICOLOGY LETTERS (2016)
Hepatotoxicity by Drugs: The Most Common Implicated Agents
Einar S. Bjornsson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos
Jaime D'Agostino et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2015)
On non-detects in qPCR data
Matthew N. McCall et al.
BIOINFORMATICS (2014)
Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway
Si Chen et al.
TOXICOLOGICAL SCIENCES (2014)
Contribution of Carboxylesterase and Cytochrome P450 to the Bioactivation and Detoxification of Isocarbophos and Its Enantiomers in Human Liver Microsomes
Xiao-Mei Zhuang et al.
TOXICOLOGICAL SCIENCES (2014)
The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells
Si Chen et al.
TOXICOLOGICAL SCIENCES (2014)
Sertraline induces endoplasmic reticulum stress in hepatic cells
Si Chen et al.
TOXICOLOGY (2014)
Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering
M. Donato et al.
CURRENT DRUG METABOLISM (2013)
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
Ulrich M. Zanger et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Mechanisms of Hepatocellular Toxicity Associated with Dronedarone-A Comparison to Amiodarone
Andrea Felser et al.
TOXICOLOGICAL SCIENCES (2013)
Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells
Kathy C. Nguyen et al.
TOXICOLOGY (2013)
Involvement of enniatins-induced cytotoxicity in human HepG2 cells
Ana Juan-Garcia et al.
TOXICOLOGY LETTERS (2013)
Mechanism study of goldenseal-associated DNA damage
Si Chen et al.
TOXICOLOGY LETTERS (2013)
Contributions of Human Enzymes in Carcinogen Metabolism
Slobodan Rendic et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2012)
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment
Laia Tolosa et al.
TOXICOLOGY IN VITRO (2012)
Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
Corie A. Ellison et al.
DRUG METABOLISM AND DISPOSITION (2012)
Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
Lei Guo et al.
DRUG METABOLISM AND DISPOSITION (2011)
Advantages of Human Hepatocyte-Derived Transformants Expressing a Series of Human Cytochrome P450 Isoforms for Genotoxicity Examination
Tsuneo Hashizume et al.
TOXICOLOGICAL SCIENCES (2010)
Cell based approaches for evaluation of drug-induced liver injury
Mhairi L. Greer et al.
TOXICOLOGY (2010)
Isomer-Specific Biotransformation Rates of a Perfluorooctane Sulfonate (PFOS)-Precursor by Cytochrome P450 Isozymes and Human Liver Microsomes
Jonathan P. Benskin et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2009)
Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract
Lei Guo et al.
FOOD AND CHEMICAL TOXICOLOGY (2009)
In vitro micronucleus test in HepG2 transformants expressing a series of human cytochrome P450 isoforms with chemicals requiring metabolic activation
Tsuneo Hashizume et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2009)
Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies
Kajsa P. Kanebratt et al.
DRUG METABOLISM AND DISPOSITION (2008)
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
James A. Dykens et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
Walter M. A. Westerink et al.
TOXICOLOGY IN VITRO (2007)
The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
Andre Guillouzo et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2007)
The 2006 Bernard B. Brodie Award Lecture - CYP2E1
Frank J. Gonzalez
DRUG METABOLISM AND DISPOSITION (2007)
Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
Nicola J. Hewitt et al.
DRUG METABOLISM REVIEWS (2007)
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
P. J. O'Brien et al.
ARCHIVES OF TOXICOLOGY (2006)
Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPARγ agonists on rat primary hepatocytes and human HepG2 cells
Lei Guo et al.
MOLECULAR DIVERSITY (2006)
Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1
LK Kamdem et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2006)
Idiosyncratic drug hepatotoxicity
N Kaplowitz
NATURE REVIEWS DRUG DISCOVERY (2005)
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics
Y Sambuy et al.
CELL BIOLOGY AND TOXICOLOGY (2005)
Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells
MP Bova et al.
TOXICOLOGY LETTERS (2005)
Comparison of established cell lines at different passages by karyotype and comparative genomic hybridization
SL Wenger et al.
BIOSCIENCE REPORTS (2004)
Comparison of primary human hepatocytes and hepatoma cell line HEPG2 with regard to their biotransformation properties
S Wilkening et al.
DRUG METABOLISM AND DISPOSITION (2003)
Human hepatocytes as a tool for studying toxicity and drug metabolism
MJ Gómez-Lechón et al.
CURRENT DRUG METABOLISM (2003)
Medical progress: Drug-induced hepatotoxicity
WM Lee
NEW ENGLAND JOURNAL OF MEDICINE (2003)
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
EFA Brandon et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology
S Yoshitomi et al.
TOXICOLOGY IN VITRO (2001)
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
FP Guengerich
CHEMICAL RESEARCH IN TOXICOLOGY (2001)
分享论文
