期刊
FUTURE ONCOLOGY
卷 13, 期 6, 页码 567-579出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2016-0475
关键词
EBV latency; EBVaGC; latent genes; lytic genes
类别
资金
- Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro - Nucleo Regional do Norte)
- Portuguese Science Foundation (FCT) [SFRH/BD/107740/2015]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/107740/2015] Funding Source: FCT
Methods: A systematic review of literature was conducted to identify all published reports regarding the expression of Epstein-Barr Virus (EBV) proteins/transcripts and EBV latency patterns in EBV-associated gastric carcinomas (EBVaGC). Results: The literature search retrieved 247 papers, of which 25 papers matched the inclusion criteria. The analysis reveals that the most frequently expressed EBV latent proteins are EBNA1 (98.1%) and LMP2A (53.8%), while LMP1 and LMP2B are present in only 10% of cases. Lytic proteins, such as BARF0 and BARF1, and other lytic transcripts are present in almost half of cases. Conclusion: EBVaGC seems to display a unique transcription/latency pattern that does not fit the 'standard' EBV latency patterns and therefore should be further studied to better understand EBVaGC carcinogenesis.
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