期刊
FUTURE ONCOLOGY
卷 13, 期 9, 页码 809-819出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2016-0266
关键词
chemoprevention; clinical trial; colorectal cancer; difluoromethylornithine; glioma pancreatic cancer
类别
Difluoromethylornithine (DFMO; eflornithine) is an irreversible suicide inhibitor of the enzyme ornithine decarboxylase which is involved in polyamine synthesis. Polyamines are important for cell survival, thus DFMO was studied as an anticancer agent and as a chemoprevention agent. DFMO exhibited mainly cytostatic activity and had single agent efficacy as well as activity in combination with other chemotherapeutic drugs for some cancers and leukemias. Herewith, we summarize the current knowledge of the anticancer and chemopreventive properties of DFMO and assess the status of clinical trials.
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