期刊
FUTURE MICROBIOLOGY
卷 12, 期 3, 页码 205-212出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2016-0113
关键词
antibiotics; bacteriocins; clinical pathogens; drug-resistance; synergy
类别
资金
- Ministry of Higher Education and Scientific Research, Republic of Tunisia
Aim: The aim of this study was to evaluate the efficacy of durancin 61A alone or in combination with nisin, pediocin PA-1, reuterin, microcin J25, vancomycin or tetracycline as an inhibitor of resistant clinical pathogens and to shed light on its mode of action. Results: Durancin and reuterin were effective inhibitors of Clostridium difficile, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus. The combination of durancin and reuterin was highly synergistic against C. difficile (fractional inhibitory concentration index = 0.2). Durancin/vancomycin combination was synergistic against S. aureus ATCC (R) 700699 (fractional inhibitory concentration index = 0.3). Conclusion & future perspective: Durancin 61A alone or combined with other bacteriocins or antibiotics may therefore provide a possible therapeutic option for the treatment of infections by these pathogens.
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