期刊
FUTURE MICROBIOLOGY
卷 12, 期 14, 页码 1247-1259出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2017-0064
关键词
Bordetella pertussis; epithelial cells; intoxication; iron delivery; outer membrane vesicles
类别
资金
- GSK Vaccines
- University of Bologna and Padova
Aim: Bordetella pertussis has been shown to release outer membrane vesicles (OMV) both in vitro and in vivo but little is known about their biological role during the initial phases of B. pertussis infection of the airways. Results: We have demonstrated that OMV are released by B. pertussis in a human ciliated-airway cell model and purified vesicles can interact with host cells. Binding and uptake are strictly Bvg-regulated and OMV-associated pertussis toxin contributes to host-cell intoxication. Furthermore, we have shown that OMV act as iron-delivery systems complementing the B. pertussis growth defect in iron-limiting conditions. Conclusion: We have proved that OMV play different roles in B. pertussis physiopathology and we opened new perspectives to be further investigated.
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