期刊
FUTURE MEDICINAL CHEMISTRY
卷 9, 期 2, 页码 199-221出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2016-0189
关键词
cancer signaling pathways; cancer therapy; cell-penetrating peptides; peptide modifications; protein-protein interactions; short interfering peptides; tumor microenvironment
资金
- National Center for Research and Development [PBS3/B7/19/2015]
- National Science Center, Poland [2014/15/B/NZ3/04704]
- Polish National Centre for Research and Development [PBS3/B7/19/2015]
Short peptides have many advantages, such as low molecular weight, selectivity for a specific target, organelles or cells with minimal toxicity. We describe properties of short peptides, which interfere with communication networks in tumor cells and within microenvironment of malignant gliomas, the most common brain tumors. We focus on ligand/receptor axes and intracellular signaling pathways critical for gliomagenesis that could be targeted with interfering peptides. We review structures and efficacy of organelle-specific and cell-penetrating peptides and describe diverse chemical modifications increasing proteolytic stability and protecting synthetic peptides against degradation. We report results of application of short peptides in glioma therapy clinical trials, their rises and falls. The most advanced examples of therapeutics such as short interfering peptides combined with cell- penetrating peptides that show good effectiveness in disease models are presented. It is foreseen that identification of peptides with better clinical properties may improve their success rates in clinical trials.
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