相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease
Jacques Joubert et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease
Ziwei Chen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
Dawid Panek et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease
Yan Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
Jakub Jerabek et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends
Sergey O. Bachurin et al.
MEDICINAL RESEARCH REVIEWS (2017)
Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors
Ornella Di Pietro et al.
PLOS ONE (2017)
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents
Urban Kosak et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography
Xiaoming Zha et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages
Felipe G. Serrano et al.
CURRENT ALZHEIMER RESEARCH (2016)
Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs
Alba Espargaro et al.
SCIENTIFIC REPORTS (2016)
Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91phox subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathway
Yang Wang et al.
SCIENTIFIC REPORTS (2016)
Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies
Irene Sola et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer's Disease: The Design of Donecopride
Christophe Rochais et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads
Frederik J. R. Rombouts et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure
Zoran Rankovic
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Reactive oxygen species: friend or foe?
Arun Kumar Sharma et al.
RSC ADVANCES (2015)
Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine-Ferulic Acid Hybrids
Mohamed Benchekroun et al.
CHEMMEDCHEM (2015)
Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties
F. Javier Perez-Areales et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Thioflavin-S Staining of Bacterial Inclusion Bodies for the Fast, Simple, and Inexpensive Screening of Amyloid Aggregation Inhibitors
S. Pouplana et al.
CURRENT MEDICINAL CHEMISTRY (2014)
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies
Ornella Di Pietro et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies
Ornella Di Pietro et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay
Anna Vallverdu-Queralt et al.
FOOD CHEMISTRY (2014)
Oxidative Stress in Alzheimer's Disease: Are We Connecting the Dots?
Michela Rosini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents
Elisabet Viayna et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Design, synthesis and evaluation of novel tacrine rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease
Su-Yi Li et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase
Florian Nachon et al.
BIOCHEMICAL JOURNAL (2013)
Core Refinement toward Permeable β-Secretase (BACE-1) Inhibitors with Low hERG Activity
Tobias Ginman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
The role of APP and BACE1 trafficking in APP processing and amyloid-beta generation
Xiaojie Zhang et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction
Montserrat Soler-Lopez et al.
BIOESSAYS (2012)
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
Stefano Rizzo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Huprine-Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer's and Prion Diseases
Caries Galdeano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors
Cyril Ronco et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Designing Multiple Ligands - Medicinal Chemistry Strategies and Challenges
Richard Morphy et al.
CURRENT PHARMACEUTICAL DESIGN (2009)
Multi-target-directed ligands to combat neurodegenerative diseases
Andrea Cavalli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Calculation of solvation free energies of charged solutes using mixed cluster/continuum models
Vyacheslav S. Bryantsev et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2008)
The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other functionals
Yan Zhao et al.
THEORETICAL CHEMISTRY ACCOUNTS (2008)
Huprines for Alzheimer's disease drug development
Diego Munoz-Torrero et al.
EXPERT OPINION ON DRUG DISCOVERY (2008)
Aqueous solvation free energies of ions and ion-water clusters based on an accurate value for the absolute aqueous solvation free energy of the proton
Casey P. Kelly et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2006)
Computational determination of aqueous pKa values of protonated benzimidazoles (part 1)
TN Brown et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2006)
Comment on Accurate experimental values for the free energies of hydration of H+, OH-, and H3O+
DM Camaioni et al.
JOURNAL OF PHYSICAL CHEMISTRY A (2005)
MST continuum study of the hydration free energies of monovalent ionic species
C Curutchet et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2005)
Antioxidant and scavenging activity of emodin, aloe-emodin, and rhein on free-radical and reactive oxygen species
FR Vargas et al.
PHARMACEUTICAL BIOLOGY (2004)
Improved second-order Moller-Plesset perturbation theory by separate scaling of parallel- and antiparallel-spin pair correlation energies
S Grimme
JOURNAL OF CHEMICAL PHYSICS (2003)
High throughput artificial membrane permeability assay for blood-brain barrier
L Di et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
Signal transduction and endocytosis: Close encounters of many kinds
A Sorkin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Absolute pKa determinations for substituted phenols
MD Liptak et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 Å resolution:: Kinetic and molecular dynamic correlates
H Dvir et al.
BIOCHEMISTRY (2002)
Experimentation with different thermodynamic cycles used for pKa calculations on carboxylic acids using complete basis set and gaussian-n models combined with CPCM continuum solvation methods
MD Liptak et al.
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY (2001)
Accurate pKa calculations for carboxylic acids using Complete Basis Set and Gaussian-n models combined with CPCM continuum solvation methods
MD Liptak et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
New tacrine-huperzine A hybrids (huprines):: Highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease
P Camps et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
分享论文
