期刊
FUTURE MEDICINAL CHEMISTRY
卷 9, 期 16, 页码 1863-1872出版社
Newlands Press Ltd
DOI: 10.4155/fmc-2017-0096
关键词
alternative animal models; antifungal development; gallates; gallic acid; infection
资金
- NIH Office of Research Infrastructure Programs
- Conselho Nacional de Pesquisa e Desenvolvimento (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/03700-9, 2014/10446-9, 2013/10917-9]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Programa de Apoio ao Desenvolvimento Cientifico da Faculdade de Ciencias Farmaceuticas da UNESP (PADC/FCF)
Aim: Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their activity against Candida albicans and their toxicity in the animal models Caenorhabditis elegans and zebrafish embryos. Results: The compounds protected worms from C. albicans infection. The dodecyl gallate was the most effective. In zebrafish embryo, gallic acid and dodecyl gallate were the least toxic. Conclusion: Gallic acid and its ester derivatives have potential for in vivo use against C. albicans infection. The antifungal effects and toxicity of gallate esters in these alternative animal models were dependent on carbon chain length.
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