4.7 Review

Concept, implementations and applications of Fourier ptychography

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NATURE REVIEWS PHYSICS
卷 3, 期 3, 页码 207-223

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SPRINGERNATURE
DOI: 10.1038/s42254-021-00280-y

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资金

  1. NSF [1510077, 2012140]
  2. UConn SPARK grant
  3. Thermo Fisher Scientific Fellowship
  4. Rosen Bioengineering Center Endowment Fund [9900050]
  5. Directorate For Engineering
  6. Div Of Chem, Bioeng, Env, & Transp Sys [1510077] Funding Source: National Science Foundation

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Fourier ptychography is an imaging approach that addresses the intrinsic trade-off between resolution and field of view in optical systems and provides computational correction of optical aberrations. This Technical Review surveys its implementations and applications.
The competition between resolution and the imaging field of view is a long-standing problem in traditional imaging systems - they can produce either an image of a small area with fine details or an image of a large area with coarse details. Fourier ptychography (FP) is an approach for tackling this intrinsic trade-off in imaging systems. It takes the challenge of high-throughput and high-resolution imaging from the domain of improving the physical limitations of optics to the domain of computation. It also enables post-measurement computational correction of optical aberrations. We present the basic concept of FP, compare it to related imaging modalities and then discuss experimental implementations, such as aperture-scanning FP, macroscopic camera-scanning FP, reflection mode, single-shot set-up, X-ray FP, speckle-scanning scheme and deep-learning-related implementations. Various applications of FP are discussed, including quantitative phase imaging in 2D and 3D, digital pathology, high-throughput cytometry, aberration metrology, long-range imaging and coherent X-ray nanoscopy. A collection of datasets and reconstruction codes is provided for readers interested in implementing FP themselves. Fourier ptychography is an imaging approach that addresses the intrinsic trade-off between resolution and field of view in optical systems and provides computational correction of optical aberrations. This Technical Review surveys its implementations and applications.

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