4.6 Article

A novel pH-responsive Fe-MOF system for enhanced cancer treatment mediated by the Fenton reaction

期刊

NEW JOURNAL OF CHEMISTRY
卷 45, 期 6, 页码 3271-3279

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj05105e

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资金

  1. National Natural Science Foundation of China [21628101, 21371031]
  2. International S&T Cooperation Program of China [2015DFG42240]
  3. Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions

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By modifying a new pH-responsive nanoreactor with the cationic polymer MV-PAH, drug delivery was notably enhanced in the weak acid environment of tumor cells, showing advanced anti-cancer effects.
Recently, the toxic hydroxyl radical (center dot OH) has received wide interest for inducing cell apoptosis by increasing the intracellular reactive oxygen species (ROS) levels. Herein, a cationic polymer (MV-PAH) was rationally synthesized, and a new pH-responsive nanoreactor (DOX@Fe-MOF@PEM) was modified with the prepared cationic polymer MV-PAH multilayers by layer-by-layer (LBL) technique. The polyelectrolyte multilayer (PEM) disassembled and notably enhanced drug delivery in the weak acid environment of the tumor cell. In the cytotoxicity and apoptosis experiments, DOX@Fe-MOF@PEM revealed an advanced repression of cancer. The H2O2 induced by DOX and MV-PAH could be catalyzed to generate hypertoxic center dot OH through intracellular iron ions based on a Fenton-like reaction, which thereby improved the anticancer effect of DOX. This realistic strategy may create a potential way to provide a combination of ROS and chemotherapy to improve the anti-cancer effect.

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