期刊
FOOD & FUNCTION
卷 12, 期 3, 页码 976-989出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo03067h
关键词
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资金
- Key Specialized Research and Development Break-through Program in Henan Province [202102110101]
- Modern Agriculture Industry Technical System of Henan Province, China [S2012-06-G02]
- National Natural Science Foundation of China [31702263, 31972715]
- Youth Backbone Teacher Project of Colleges and Universities of Henan Province [2020GGJS163]
- Young Talent Lifting Project in Henan Province [2021HYTP038]
Selenium, an essential trace element in the body, plays a crucial role in immune function and cellular activity. Maintaining a suitable selenium concentration is important for normal cellular function, as decreased levels can impact tissue and cell physiological functions. Selenium also influences immune function regulation through different signaling pathways.
Selenium, an essential trace element in the body, participates in various biological processes in the form of selenoproteins. In humans, a suitable concentration of selenium is essential for maintaining normal cellular function. Decreased levels of selenoproteins can lead to obstruction of the normal physiological functions of tissues and cells and even death. In addition, the level of selenium in the body affects cellular immunity, humoral immunity, and the balance between type 2 and type 1 helper T cells. Selenium can affect the immune function of the body through the reactive oxygen species (ROS), NF-kappa B, ferroptosis and NRF2 pathways. This paper reviews the immune effect of selenium on the body and the process of signal transduction and aims to serve as a reference for follow-up studies of immune function and research on the development of new selenium compounds and active targets.
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