Gut microbiota metabolites in autistic children: An epigenetic perspective

Gut microbiota has become an issue of great importance recently due to its major role in autism spectrum disorder (ASD). Over the past three decades, there has been a sustained research activity focused to explain the actual mechanism by which gut microbiota triggers/develops autism. Several genetic and epigenetic factors are involved in this disorder, with epigenetics being the most active area of research. Although the constant investigation and advancements, epigenetic implications in ASD still need a deeper functional/causal analysis. In this review, we describe the major gut microbiota metabolites and how they induce epigenetic changes in ASD along with interactions through the gut-brain axis.

Automated summary

In autism spectrum disorder (ASD), gut microbiota metabolites induce epigenetic changes through the gut-brain axis, with genetic and epigenetic factors playing important roles in the disorder.