期刊
HELIYON
卷 7, 期 1, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2021.e05925
关键词
Probiotics; Oxidative stress; C-reactive protein; Diabetic nephropathies; Meta-analysis
资金
- Isfahan University of Medical Sciences, Isfahan, Iran [CRD42020186189]
Probiotics have been shown to significantly reduce hs-CRP and MDA levels, while increasing GSH and TAC levels in patients with Diabetic Nephropathy. This suggests that probiotics may have a beneficial effect on inflammation and oxidative stress in this population.
This systematic review and meta-analysis was performed to evaluate the effect of probiotics on serum high sensitivity-C reactive protein (hs-CRP) and oxidative stress biomarkers among patients with Diabetic Nephropathy (DN). Electronic databases were searched through May 10, 2020. Seven trials that included 340 patients were identified for analysis. Meta-analysis indicated that probiotics significantly reduced hs-CRP (WMD = -1.53 mg/L; 95% CI = -2.38, -0.69; P < 0.001) and Malondialdehyde (MDA) (WMD = -0.62 mu mol/L; 95% CI = -1.18, -0.06; P = 0.030) levels in DN patients, whereas they increased Glutathione (GSH) (WMD = 73.84 mu mol/L; 95% CI = 24.3, 123.29; P = 0.003) and Total Antioxidant Capacity (TAC) (WMD = 26.54 mmol/L; 95% CI = 6.23, 46.85; P = 0.010). Therefore, probiotics may improve hs-CRP and oxidative stress biomarkers in DN population.
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