期刊
BIOENGINEERED
卷 12, 期 1, 页码 673-681出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2021.1878763
关键词
Long non-coding RNAs; hepatocellular carcinoma; prognosis; The Cancer Genome Atlas; overall survival
资金
- Natural Science Foundation of China [81974312, 81501823]
- Zhejiang Provincial Natural Science Foundation of China [Y18H160217, LQ19H160008]
- medical scientific research of Zhejiang Province [2017KY459]
- Wenzhou municipal Science and Technology Bureau [Y20190203]
This study established a 19-lncRNA signature to predict the prognosis of hepatocellular carcinoma (HCC) patients. The signature, combined with clinicopathologic factors, showed high predictive performance and may play a crucial role in guiding the management of HCC.
Long non-coding RNAs (lncRNAs), as one common type of non-coding RNAs, play a critical role in the tumorigenesis and development of hepatocellular carcinoma (HCC). In the current study, we aimed to assess the correlation between lncRNAs expression levels and prognosis of HCC patients. A lncRNA-based signature was also developed to predict the prognosis of HCC in this work. The lncRNAs expression profiles in tissues of tumor and para-carcinoma were obtained from The Cancer Genome Atlas (TCGA) database. The lncRNA-based prognostic model was established by least absolute shrinkage and selection operator (LASSO). The multivariate Cox-regression analysis was applied to identify the independent risk factors and subsequently developed a prognostic nomogram. Based on the co-expression analyses, we identi?ed the lncRNA-related mRNAs and performed the biological function analysis. Between HCC and para-carcinoma tissues, 220 differentially expressed lncRNAs were filtered. Among these lncRNAs, 19 lncRNAs were identified as prognostic factors and were used to build a prognostic signature of overall survival (OS). Furthermore, a nomogram with high performance for predicting the OS of HCC patients (C-index: 0.779) by combining the 19-lncRNA signature (P < 0.001) and clinicopathologic factors including HBV (P = 0.005) and stage (P =0.017) was established. Functional enrichment analysis revealed that 19 lncRNAs had potential effects on tumor cell proliferation in HCC. In summary, we established a 19-lncRNA signature to predict the prognosis of HCC patients, which may perform a crucial role in guiding the management of HCC.
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