期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 14, 页码 1734-1737出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc08191d
关键词
-
资金
- National Natural Science Foundation of China [51973089]
- Shenzhen Science and Technology Innovation Commission [KQTD2017081 0111314625]
- Shenzhen Fundamental Research Programs [JCYJ20170817105645935]
This nanoparticle utilizes high-molecular-weight DNA as a carrier to efficiently deliver and release Mn2+ in cancer cells, resulting in high toxicity through a Fenton-like reaction.
A kind of nanoparticle is developed for highly efficient chemodynamic therapy that only relies on the endogenous H2O2 of cancer cells. For this nanoparticle, high-molecular-weight DNA is used as the biocompatible carrier to load abundant Mn2+ ions. Therefore, the resultant Mn-DNA coordination nanoparticles can efficiently deliver and sensitively release Mn2+ in cancer cells, resulting in high toxicity through the Fenton-like reaction.
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