期刊
NANOSCALE
卷 13, 期 10, 页码 5383-5399出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr08831e
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资金
- National Nature Scientific Foundation [82073380, 817013538, 81803094, 81225010]
- National Foundational Basic Research Project of China [2017YFA0205301]
- National Key Research and Development Program of China [2017YFC1200904]
By synthesizing and loading specific substances, the Fe3O4@MnO2-celastrol/Ce6 nanoplatform can achieve combined imaging and drug release targeting tumor characteristics, optimize chemotherapy and photodynamic therapy, release drugs in the tumor microenvironment, and generate Mn2+ and O-2.
Early diagnosis of tumors is crucial in selecting appropriate treatment options to achieve the desired therapeutic effect, but it is difficult to accurately diagnose cancer by a single imaging modality due to technical constraints. Therefore, we synthesized a type of Fe3O4 nanoparticle with manganese dioxide grown on the surface and then prepared it by loading photosensitive drugs and traditional Chinese medicine monomers to create an integrated diagnosis/treatment multifunctional nanoplatform: Fe3O4@MnO2-celastrol (CSL)/Ce6. This nanoplatform can have full advantage of the tumor microenvironment (TME) characteristics of hypoxia (hypoxia), acidic pH (acidosis), and increased levels of reactive oxygen species (e.g., H2O2), even outside the TME. Specific imaging and drug release can also enhance tumor therapy by adjusting the hypoxic state of the TME to achieve the combined effect of chemotherapy (CT) and photodynamic therapy (PDT). Moreover, the obtained Fe3O4@MnO2-CSL/Ce6 has H2O2- and pH-sensitive biodegradation and can release the anticancer drug celastrol (CSL) and photosensitizer Ce6 in TME and simultaneously generate O-2 and Mn2+. Therefore, the dual response synergistic strategy also confers specific drug release on nanomaterials, relieves tumor hypoxia and antioxidant capacity, and achieves significant optimization of CT and PDT. Furthermore, the resulting Mn2+ ions and Fe3O4 nanoparticles can be used for T-1/T-2 magnetic resonance imaging on tumor-bearing mice, and the released Ce6 can simultaneously provide fluorescence imaging functions. Therefore, Fe3O4@MnO2-CSL/Ce6 realized the synergistic treatment of PDT and CT under multimodal near-infrared fluorescence/photoacoustic (photoacoustic) imaging monitoring, showing its great potential in the accurate medical treatment of tumors.
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