期刊
FUNGAL GENETICS AND BIOLOGY
卷 104, 期 -, 页码 38-44出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.fgb.2017.03.003
关键词
Filamentous fungi; Yeast; Mass spectrometry; Phosphorylation; Cellular regulation
资金
- National Science Foundation [1517309, 1601935]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1517309, 1516905] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1601935] Funding Source: National Science Foundation
Protein phosphorylation is a major means of regulation for cellular processes, and is important in cell signaling, growth, and cell proliferation. To study phosphorylated proteins, high throughput phosphoproteomic technologies, such as reverse phase protein array, phospho-specific flow cytometry, and mass spectrometry (MS) based technologies, have been developed. Among them, mass spectrometry has become the primary tool employed for the identification of phosphoproteins and phosphosites in fungi, leading to an improved understanding of a number of signaling pathways. Using mass spectrometry techniques, researchers have discovered new kinase substrates, established connections between kinases and fungal pathogenicity, and studied the evolutionary lineage of kinases between different fungal species. Further, many specific phosphorylation sites recognized by individual kinases have been described. In this review, we will focus on recent discoveries made in yeast and filamentous fungi using phosphoproteomic analysis. (C) 2017 Elsevier Inc. All rights reserved.
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