期刊
MICROBIAL CELL
卷 8, 期 2, 页码 28-56出版社
SHARED SCIENCE PUBLISHERS OG
DOI: 10.15698/mic2021.02.741
关键词
biofilm-associated disease; nosocomial infections; Vibrio cholerae; Pseudomonas aeruginosa; staphylococci; treatment; biofilm
资金
- Austrian FWF [P27654, P32577, W901-B12, DOC-50]
- BioTechMed Graz
- City of Graz
- DocAcademy Graz
- Land Steiermark
- Austrian Science Fund (FWF) [P32577, P27654] Funding Source: Austrian Science Fund (FWF)
Bacterial biofilm formation is increasingly recognized as a passive virulence factor in infectious disease processes. This review focuses on biofilms formed by human pathogens, particularly examining those of Vibrio cholerae, Pseudomonas aeruginosa, and Staphylococcus spp., and discussing therapeutic intervention strategies targeting biofilms.
Notably, bacterial biofilm formation is increasingly recognized as a passive virulence factor facilitating many infectious disease processes. In this review we will focus on bacterial biofilms formed by human pathogens and highlight their relevance for diverse diseases. Along biofilm composition and regulation emphasis is laid on the intensively studied biofilms of Vibrio cholerae, Pseudomonas aeruginosa and Staphylococcus spp., which are commonly used as biofilm model organisms and therefore contribute to our general understanding of bacterial biofilm (patho-)physiology. Finally, therapeutical intervention strategies targeting biofilms will be discussed.
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