期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 8, 页码 1050-1053出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06980a
关键词
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资金
- Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2019R01005]
- Natural Science Foundation of Zhejiang Province [LY18B020002, LQ20B020005]
- Joint Fund of Zhejiang Provincial Natural Science Foundation [LTZ21B020001]
A novel method catalyzed by HFIP for the synthesis of various α,α-difluoroketones has been developed, which are important intermediates in medicinal and organic chemistry. Moreover, this method can also be applied in the late-stage dehydroxydifluoroalkylation of compounds.
Hexafluoroisopropanol (HFIP)-catalyzed direct dehydroxydifluoro-alkylation of benzylic and allylic alcohols with difluoroenoxysilanes is developed. This procedure enables the synthesis of a broad range of alpha,alpha-difluoroketones, a class of highly valuable intermediates and building blocks in medicinal and organic chemistry. Here, we have demonstrated for the first time that HFIP could act as a powerful catalyst for fluorinated carbon-carbon bond formation. The application of this protocol in late-stage dehydroxydifluoroalkylation of potentially bioactive drugs and natural products has also been carried out.
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