Electrochemical oxidative thiocyanation and amination of enaminones towards the synthesis of multi-substituted alkenes

A highly stereoselective synthesis of thiocyanated enaminones was achieved by an electrochemical process, which involved C-H bond thiocyanation and vinyl C-N bond transamination. Various aryl enaminones were compatible, generating the desired thiocyanated enaminones in up to 87% yields. This transformation proceeded smoothly without an external oxidant, a supporting electrolyte and a transition-metal catalyst. Gram-scale synthesis showed the potential of this protocol for practical application.

Automated summary

A highly stereoselective synthesis of thiocyanated enaminones was achieved through an electrochemical process, with up to 87% yields. The transformation proceeded smoothly without the need for external oxidants, electrolytes, or transition-metal catalysts, showcasing its potential for practical application.