Peptide-based supramolecular hydrogels for bioimaging applications

Owing to their superior loading capacity and biocompatibility, imaging agent-conjugated (or encapsulated) peptide-based supramolecular hydrogels are capable of imaging in vivo biological events with enhanced signals. Notably, by rational design of the hydrogelators, the hydrogelation process can smartly occur on the pathological site (or region of interest), rendering precise and sensitive bioimaging of the disease (or event) in vivo. Considering their importance in disease diagnosis, herein, we provide a review on the recent advances in peptide-based supramolecular hydrogels for bioimaging applications. Besides, we provide an outlook on the challenges (or chances) for these types of biomaterials in the field of bioimaging.

Automated summary

Peptide-based supramolecular hydrogels with superior loading capacity and biocompatibility offer enhanced signal imaging for in vivo biological events. Through rational design of hydrogelators, the hydrogelation process can intelligently occur at pathological sites, allowing precise and sensitive bioimaging of diseases in vivo. Despite their importance in disease diagnosis, these biomaterials still face challenges in the field of bioimaging.