期刊
ORGANOMETALLICS
卷 40, 期 7, 页码 813-831出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.1c00030
关键词
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资金
- NIH [5R01GM121441]
- Amgen
- Princeton University
This tutorial presents the factors determining selectivity in C-(sp(2))-H activation and functionalization reactions involving two-electron oxidative addition processes with transition metals. It discusses the interplay of thermodynamics and kinetic influences on regioselectivity, along with valuable experimental and computational results from the literature. Mechanisms and energetics of chelate-assisted C-(sp(2))-H oxidative addition are examined, as well as concepts related to chemoselectivity in the oxidative addition of C-(sp(2))-H or C-(sp(2))-X (X = F, Cl, Br, I) bonds with aryl halide substrates.
A Tutorial on factors that determine the selectivity in C-(sp(2))-H activation and functionalization reactions involving two-electron oxidative addition processes with transition metals is presented. The interplay of the thermodynamics of C-(sp(2))-H oxidative addition and kinetic influences upon regioselectivity are presented alongside pedagogically valuable experimental and computational results from the literature. Mechanisms and energetics of chelate-assisted C-(sp(2))-H oxidative addition are examined, as are concepts related to chemoselectivity in the oxidative addition of C-(sp(2))-H or C-(sp(2))-X (X = F, Cl, Br, I) bonds with aryl halide substrates.
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