期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 17, 期 1, 页码 328-338出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.52290
关键词
MED13; cardiovascular diseases; energy metabolism
资金
- National Key R&D Program of China [2016YFC0900903]
- First Hospital of Jilin University, Changchun, China [11/2018-3/2021]
MED13 plays critical roles in cell cycle regulation, development, growth, myocardial energy metabolism, and non-metabolic cardiovascular diseases. It is a potential therapeutic target for metabolic disorders and cardiovascular diseases.
Mediator complex subunit 13 (MED13, previously known as THRAP1 and TRAP240) is a subunit of the cyclin-dependent kinase 8 (CDK8) kinase module in the eukaryotic mediator complex. MED13 has been known to play critical roles in cell cycle, development, and growth. The purpose of this review is to comprehensively discuss its newly identified potential roles in myocardial energy metabolism and non-metabolic cardiovascular diseases. Evidence indicates that cardiac MED13 mainly participates in the regulation of nuclear receptor signaling, which drives the transcription of genes involved in modulating cardiac and systemic energy homeostasis. MED13 is also associated with several pathological conditions, such as metabolic syndrome and thyroid disease-associated heart failure. Therefore, MED13 constitutes a potential therapeutic target for the regulation of metabolic disorders and other cardiovascular diseases.
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