期刊
JGH OPEN
卷 5, 期 4, 页码 434-445出版社
WILEY
DOI: 10.1002/jgh3.12512
关键词
BMI; geographic region; NAFLD; pooled odds ratio; study quality
资金
- Fonds de la Recherche en Sante du Quebec [27127, 267806]
- Department of Medicine of McGill University
- Libyan Ministry of Higher Education and Scientific Research through the Canadian Bureau for International Education
This meta-analysis revealed a 2.5-fold increased risk of NAFLD in premenopausal PCOS patients compared to controls, with BMI identified as the main cofactor influencing this association.
Background and Aim: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are prevalent conditions sharing common pathogenic factors. We performed a systematic literature review and meta-analysis aiming to investigate the association between NAFLD and PCOS among premenopausal PCOS patients. Methods: Relevant studies were systematically identified from scientific databases until 2019. We calculated pooled odds ratio (OR) using a random-effect model, and heterogeneity was addressed through I-2. Subgroup analyses and meta-regression for various covariates were performed. Results: Of the 1833 studies retrieved, 23 studies with 7148 participants qualified for quantitative synthesis. The pooled result showed that women with PCOS had a 2.5-fold increase in the risk of NAFLD compared to controls (pooled OR 2.49, 95% confidence interval [CI] 2.20-2.82). In subgroup analyses comparing PCOS to controls, South American/Middle East PCOS patients had a greater risk of NAFLD (OR 3.55, 95% CI 2.27-5.55) compared to their counterpart from Europe (OR 2.22, 95% CI 1.85-2.67) and Asia (OR 2.63, 95% CI 2.20-3.15). Insulin resistance and metabolic syndrome were more frequent in the PCOS group (OR 1.97, 95% CI 1.44-2.71 and OR 3.39, 95% CI 2.42-4.76, respectively). Study quality and body mass index (BMI) were the only covariates that showed a relationship with the outcome in the meta-regression, with a regression coefficient of -2.219 (95% CI -3.927 to -0.511) and -1.929 (95% CI -3.776 to -0.0826), respectively. Conclusions: This meta-analysis indicates that premenopausal PCOS patients are associated with 2.5-fold increase in the risk of NAFLD, and BMI seems to be the main cofactor.
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