期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 6, 期 1, 页码 55-70出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.11.007
关键词
appetite; blood pressure; cardiac metabolism; heart failure; MC4R
资金
- National Heart, Lung, and Blood Institute [P01 HL51971, R01HL136438, RO1 HL136438-01A1]
- National Institute of General Medical Sciences [P20 GM104357, U54 GM115428]
- National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK121411]
The study shows that activation of the central nervous system leptin-melanocortin pathway provides remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors, improving cardiac substrate oxidation, cardiomyocyte contractility, Ca2+ coupling, and mitochondrial efficiency. These findings suggest a potentially novel therapeutic approach for myocardial infarction and heart failure.
Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca2+ coupling, and mitochondrial efficiency. These findings highlight a potentially novel therapeutic approach for myocardial infarction and heart failure. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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