期刊
WORLD JOURNAL OF HEPATOLOGY
卷 13, 期 1, 页码 -出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4254/wjh.v13.i1.80
关键词
Non-alcoholic fatty liver disease; Metabolic phenotype; Lean individuals; Insulin resistance; Visceral fat tissue; Sarcopenia
The development of NAFLD in lean individuals is interconnected with metabolic phenotype, insulin resistance, and body fat distribution; more appropriate tools are suggested for screening high-risk patients.
Non-alcoholic fatty liver disease (NAFLD) has become a significant public health burden affecting not only obese individuals but also people with normal weight. As opposed to previous beliefs, this particular subset of patients has an increased risk of all-cause mortality and worse outcomes than their obese counterparts. The development of NAFLD in lean subjects seems to be interconnected with metabolic phenotype, precisely visceral fat tissue, sarcopenia, and insulin resistance. Here, we summarize available data focusing on the co-dependent relationship between metabolic phenotype, insulin resistance, and development of NAFLD in lean individuals, suggesting more appropriate tools for measuring body fat distribution for the screening of patients at risk.
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