Visible-light promoted α-alkylation of glycine derivatives with alkyl boronic acids

A visible-light-mediated aerobic alpha-alkylation reaction of glycine derivatives with alkyl boronic acids has been established in the presence of a Ru/Cu catalyst system, giving the desired radical coupling products efficiently. The transformation features mild reaction conditions and broad substrate scope, delivering a wide range of complex unnatural alpha-amino-acid derivatives.

Automated summary

This method utilizes a visible-light-mediated aerobic alpha-alkylation reaction of glycine derivatives with alkyl boronic acids in the presence of a Ru/Cu catalyst system to efficiently produce a wide range of complex unnatural alpha-amino-acid derivatives. It features mild reaction conditions and broad substrate scope.