Palladium-catalyzed selective B(3)-H arylation of o-carboranes with arylboronic acids at room temperature

A palladium-catalyzed selective B(3)-H arylation of o-carboranes at room temperature has been developed using readily available arylboronic acids as the aryl source, and the corresponding 3-aryl-o-carboranes were obtained in good to excellent yields. This method provides a powerful synthetic route for constructing polysubstituted o-carborane derivatives.

Automated summary

A palladium-catalyzed selective B(3)-H arylation of o-carboranes at room temperature has been developed, using readily available arylboronic acids as the aryl source. The method provides an efficient synthetic route for constructing polysubstituted o-carborane derivatives.