期刊
NATURAL PRODUCT COMMUNICATIONS
卷 16, 期 2, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X21996180
关键词
marine bryozoan; Securiflustra securifrons; alkaloids; bioactivity; marine bioprospecting
资金
- UiT
A fraction from the Arctic marine bryozoan Securiflustra securifrons showed antimicrobial activity against the human pathogenic bacterium Streptococcus agalactiae, containing several variants of securamines. These securamines are alkaloids with a common isoprene-histamine-tryptamine backbone.
Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan Securiflustra securifrons was found to be active against the human pathogenic bacterium Streptococcus agalactiae (gr. B). Chemical investigation of the fraction revealed that it contained several variants of the highly modified secondary metabolites known as securamines. The securamines are alkaloids sharing a common isoprene-histamine-tryptamine backbone. In this study, we describe the antimicrobial activities of securamine C, E, and H - J (4, 5, and 1-3) and the attempt to deconvolute the mode of action of 1.
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