期刊
ACS APPLIED BIO MATERIALS
卷 4, 期 2, 页码 1969-1975出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01597
关键词
manganese-doped carbon dots; one-step solvothermal method; orange emission; fluorescence imaging; magnetic resonance imaging
资金
- National Natural Science Foundation of China [51772074, U1732127, U20A20254]
- Natural Science Foundation of Hebei Province [C2020201025]
- Natural Science Interdisciplinary Research Program of Hebei University [DXK202002]
- Advanced Talents Incubation Program of Hebei University [521000981076]
- Youth Top-notch Talents of Education Department of Hebei Province [BJ2017002]
Metal-doped carbon dots (CDs) show potential in fluorescence and magnetic resonance (MR) imaging, with manganese-doped CDs (Mn-CDs) synthesized for enhanced performance, uniform size distribution, increased fluorescence intensity, and high T-1-weighted MR imaging capabilities, making them promising dual-modal nanoprobe candidates.
Metal-doped carbon dots (CDs) exhibited promising application in fluorescence and magnetic resonance (MR) imaging, but developing manganese-doped CDs (Mn-CDs) with long wavelength emission and enhanced MR performance is a challenge. Herein, using a one-step solvothermal method, Mn-CDs with redshifted orange emission and enhanced longitudinal relaxation were synthesized for fluorescence and MR imaging. The results indicated that the prepared Mn-CDs had a uniform size distribution, and the average size was 5 nm. Moreover, Mn-CDs possessed a stronger fluorescence performance than Mn-free CDs, and simultaneously, the emission wavelength can redshift from S42 nm (green emission) to 578 nm (orange emission), owing to the increasing N-doping. Because of the movement limit of Mn2+, Mn-CDs exhibited high T-1-weighted MR imaging performance with a longitudinal relaxation rate of 12.69 mM(-1).s(-1). The in vivo experiments demonstrated their excellent fluorescence and MR imaging with safety and reliability. Therefore, the prepared Mn-CDs with orange emission can be an excellent candidate as a dual-modal nanoprobe for fluorescence and MR imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据