期刊
ACS APPLIED BIO MATERIALS
卷 4, 期 2, 页码 1544-1551出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01402
关键词
antibiotic resistance; antibiotic pollution; antimicrobial materials; antimicrobial polymers; degradable polymers
资金
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
A new type of imidazolium polymers with excellent antimicrobial activity has been reported in this study, which can degrade in the environment without inducing bacterial resistance. These polymers show moderate biodegradation in surface water.
Globally, over 100,000 tons of antibiotics are consumed each year with a significant proportion discharged into the environment. As antibiotic usage continues to rise, there is a pressing need to reduce antibiotic pollution by developing antimicrobials whose activity can be switched off after the material has served its intended purpose. We have reported a series of imidazolium polymers incorporating pH-degradable linkers. The polymers show excellent antimicrobial activity across a range of Gram-positive and Gram-negative bacteria and fungi. The introduction of pH-degradable linkers was demonstrated to facilitate environmental degradation of the polymers to inactive small molecules. Both polymers and their degradation products do not induce bacterial resistance and display moderate biodegradation in surface water.
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