期刊
DALTON TRANSACTIONS
卷 50, 期 7, 页码 2570-2584出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0dt03858j
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Novel compounds including silicon(iv) phthalocyanine derivatives were synthesized, characterized and their photophysicochemical properties were studied. The effects of quaternization on these phthalocyanines were determined, and the cytotoxicity of water soluble silicon phthalocyanines against cancer cell lines was demonstrated through photodynamic therapy activities.
In this study, compounds 1 and 2, and their silicon(iv) phthalocyanine (SiPc) derivatives 3 and 4, which bear these ligands as substituents on the axial positions were synthesized. These SiPcs (3 and 4) were also converted to their water soluble derivatives (3a and 4a). All these novel compounds were fully characterized by a combination of spectroscopic data such as FT-IR, H-1-NMR, C-13-NMR and UV-vis as well as mass spectroscopy. The photophysicochemical properties (fluorescence quantum yields and lifetimes, singlet oxygen, and photodegradation quantum yields) were investigated in DMSO for all the studied SiPcs (3 and 4) and in both DMSO and aqueous solutions for the water soluble SiPcs (3a and 4a). Effects of quaternization of these phthalocyanines on photophysicochemical properties were also determined. The photodynamic therapy activities of the water soluble SiPcs (3a and 4a) were tested against to the HeLa cancer cell lines and these phthalocyanines exhibited cytotoxicity against these cell lines.
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