期刊
ACS APPLIED BIO MATERIALS
卷 4, 期 2, 页码 1221-1228出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01518
关键词
metal-organic framework; organosilica; hybrid nanocomposite; multicompartment porous nanomaterials; bioapplication
资金
- National Natural Science Foundation of China [21972047, 52003086]
- Guangdong Provincial Pearl River Talents Program [2019QN01Y314]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2019ZT08Y318]
- China Postdoctoral Science Foundation [2020M672625]
- National Institutes of Health (NIH) [R01 CA226537]
By utilizing the polyhedral effects/characteristics of metal-organic frameworks (MOFs), a versatile approach to construct MOF-organosilica hybrid branched nanocomposites with MOF cores, SiO2 shells, and periodic mesoporous organosilica (PMO) branches is presented. The morphology, structure, and functions of these hybrid nanocomposites can be easily modulated by varying particle size, shape, or crystalline structures of the MOF cores. These branched multicompartment porous nanoparticles exhibit different behaviors in different cells, showing great potential as a vehicle for immunotherapy.
The structural modulation of multicompartment porous nanomaterials is one of the major challenges of nanoscience. Herein, by utilizing the polyhedral effects/characteristics of metal-organic frameworks (MOFs), we present a versatile approach to construct MOF-organosilica hybrid branched nanocomposites with MOF cores, SiO2 shells, and periodic mesoporous organosilica (PMO) branches. The morphology, structure, and functions of the obtained hybrid nanocomposites can be facilely modulated by varying particle size, shape, or crystalline structures of the MOF cores. Specifically, these branched multicompartment porous nanoparticles exhibit evasion behaviors in epithelial cells compared with macrophage cells, which may endow them great potential as a vehicle for immunotherapy.
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