4.1 Article

Identification of Novel MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating the EGFR-ADAM17 Axis: An In Silico Analysis

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ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
卷 4, 期 1, 页码 396-399

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AMER CHEMICAL SOC
DOI: 10.1021/acsptsci.0c00199

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SARS-CoV-2; microRNA; ADAM17; EGFR; breast cancer

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Cancer patients with COVID-19 may face worsened prognosis due to inflammation and lymphopenia, but miRNAs could potentially be a new therapeutic target in treating breast cancer.
Cancer patients contracting SARS-CoV-2 encounter additional challenges due to inflammatory bursts and lymphopenia, which may aggravate breast cancer prognosis. In this in silico analysis, we identified the potential of miRNAs as new therapeutic targets to treat breast cancer patients infected with COVID-19 via the regulation of ADAM17 and EGFR expression microRNAs.

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