Catalyst- and additive-free selective sulfonylation/cyclization of 1,6-enynes with arylazo sulfones leading to sulfonylated γ-butyrolactams

A convenient and regioselective sulfonylation/cyclization of 1,6-enynes with arylazo sulfones has been developed to access a series of sulfonylated gamma-butyrolactams. The present reaction could be efficiently conducted under catalyst- and additive-free conditions, in which C-S and C-C bonds were selectively constructed in one-pot procedure. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

A convenient and regioselective sulfonylation/cyclization method has been developed for the synthesis of sulfonylated gamma-butyrolactams. The reaction can be efficiently conducted under catalyst- and additive-free conditions, selectively constructing C-S and C-C bonds in one-pot procedure.