期刊
GREEN CHEMISTRY
卷 23, 期 7, 页码 2619-2623出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1gc00270h
关键词
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资金
- National Natural Science Foundation of China [21772138, 21672157]
- Project of Scientific and Technologic Infrastructure of Suzhou [SZS201708]
- PAPD
The newly developed method for synthesizing spiroindolenine derivatives features high atom economy, excellent yields, wide substrate scopes, and recyclable aqueous catalytic system, making it a green and efficient approach for constructing spiroindolenine derivatives.
A Co-catalyzed coupling of 3-(2-isocyanoethyl)indoles with organic azides in pure water for accessing spiroindolenine derivatives was developed. This strategy features mild reaction conditions, high atom-economy, excellent yields, wide substrate scopes, and broad functional group tolerance. The products were obtained simply by sequential operation involving extraction, concentration, precipitation, and filtration, without tedious column chromatography. More importantly, the aqueous catalytic system could be recycled at least ten times without reducing the catalytic activity. The strategy provides a green and efficient method for the construction of spiroindolenine derivatives.
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