期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 109, 期 -, 页码 48-60出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2017.01.027
关键词
Redox regulation; Inflammation; Endothelial dysfunction; ENOS uncoupling; Low-grade inflammation
资金
- European Cooperation in Science and Technology [COST Action BM1203/EU-ROS]
- Stiftung Mainzer Herz
- German Center for Cardiovascular Research (DZHK)
- Center of Thrombosis and Hemostasis (CTH) - German Federal Ministry for Education and Research [BMBF 01EO1503]
- Centre of Translational Vascular Biology (CTVB), Medical Center of the Johannes Gutenberg University (Mainz, Germany)
Oxidative stress is a major hallmark of cardiovascular diseases although a causal link was so far not proven by large clinical trials. However, there is a close association between oxidative stress and inflammation and increasing evidence for a causal role of (low-grade) inflammation for the onset and progression of cardiovascular diseases, which may serve as the missing link between oxidative stress and cardiovascular morbidity and mortality. With the present review we would like to highlight the multiple redox regulated pathways in inflammation, discuss the sources of reactive oxygen and nitrogen species that are of interest for these processes and finally discuss the importance of angiotensin II (AT-II) as a trigger of cardiovascular inflammation and the initiation and progression of cardiovascular diseases.
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