期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 107, 期 -, 页码 2-12出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2017.03.030
关键词
DNA oxidation; DNA damage; DNA repair; Thomas Lindahl; Nobel Prize; Oxidative stress
资金
- National Institute of Environmental Health Sciences of the US National Institutes of Health [ES 003598]
- National Institute on Aging of the US National Institutes of Health [AG 052374]
This introductory article should be viewed as a prologue to the Free Radical Biology & Medicine Special Issue devoted to the important topic of Oxidatively Damaged DNA and its Repair. This special issue is dedicated to Professor Tomas Lindahl, co-winner of the 2015 Nobel Prize in Chemistry for his seminal discoveries in the area repair of oxidatively damaged DNA. In the past several years it has become abundantly clear that DNA oxidation is a major consequence of life in an oxygen-rich environment. Concomitantly, survival in the presence of oxygen, with the constant threat of deleterious DNA mutations and deletions, has largely been made possible through the evolution of a vast array of DNA repair enzymes. The articles in this Oxidatively Damaged DNA & Repair special issue detail the reactions by which intracellular DNA is oxidatively damaged, and the enzymatic reactions and pathways by which living organisms survive such assaults by repair processes.
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