Atropisomerism as inspiration for new chemistry

Atropisomerism is a type of chirality that is ubiquitous but often overlooked in modern drug discovery. In this Account we discuss studies on leveraging atropisomerism as a design principle in medicinal chemistry, and how this work led to several seemingly disparate projects that began due to synthetic challenges associated with accessing pharmaceutically relevant atropisomers. [GRAPHICS] .

Automated summary

Atropisomerism, a commonly overlooked type of chirality, plays an important role in modern drug discovery and can be utilized as a design principle in medicinal chemistry. Leveraging Atropisomerism in drug design can help address synthetic challenges and lead to seemingly disparate projects.