Pyrazole-carboxaldehydes as versatile precursors for different pyrazole-substituted heterocyclic systems

In the last decade, interest in pyrazole chemistry has grown considerably due to the discovery of fascinating properties demonstrated by a large number of pyrazole derivatives. They occur in a wide range of natural products, dyes, and as scaffolds in a number of drugs and associated pharmaceutical active substances. Substantial attention has been paid to the creation of hybrid molecules in which two heterocycles are bound in a single molecule to enhance their biological effectiveness and overcome drug resistance. In this regard, this review illustrated various methods for the construction of pyrazole-substituted heterocycles and their corresponding fused derivatives using pyrazole carboxaldehydes as effective precursors. The heterocyclic systems mentioned in this review are categorized according to the type of the heterocyclic systems. [GRAPHICS] .

Automated summary

Interest in pyrazole chemistry has increased significantly in the past decade due to the fascinating properties demonstrated by numerous pyrazole derivatives. Researchers have focused on creating hybrid molecules to enhance biological effectiveness and have explored various methods for constructing pyrazole-substituted heterocycles using pyrazole carboxaldehydes as effective precursors.