期刊
PHARMACOLOGY
卷 106, 期 5-6, 页码 305-315出版社
KARGER
DOI: 10.1159/000513376
关键词
Binge-eating behaviour; 1-Boc-piperidine-4-carboxaldehyde; Piperidine derivatives; Anxiety; Molecular modelling; GPCRs
资金
- Programa para el Desarrollo Profesional Docente para el Tipo Superior (PRODEP) [UAAPTC-200]
- Direccion General de Investigacion y Posgrado [PIBB19-1]
- Consejo Nacional de Ciencia y Tecnologia (CONACYT)
- Secretaria de Investigacion y Posgrado del Instituto Politecnico Nacional
1-Boc-piperidine showed dose-dependent inhibition on binge-eating behavior in female rats and exhibited anxiolytic effects in male rats. However, the mechanism of action of this piperidine remains to be characterized.
Background: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. In this context, 1-Boc-piperidine-4-carboxaldehyde (1-Boc-piperidine) is a piperidine-derivative molecule with no mechanism of action reported, although its uses include the synthesis of GPR119 selective agonists that have been patented as anti-obesity drugs. Objectives: The aim of this work was to study the effects of 1-Boc-piperidine on binge-eating behaviour and anxiety in Wistar rats. Methods: In experimental protocol 1, binge-eating behaviour was induced in animals that received pre-treatment (i.p.) with (i) vehicle (methanol 10%; 1 mL/kg), (ii) 1-Boc-piperidine (1 mu mol kg(-1)), or (iii) 1-Boc-piperidine (10 mu mol kg(-1)). In experimental protocol 2, mildly stressed animals were evaluated in the elevated plus maze under the acute effects of the pre-treatments applied in experimental protocol 1. Results and Conclusions: 1-Boc-piperidine decreased, in a dose-dependent manner, the intake of calories from a succulent hyper-caloric food in a binge-eating protocol in female rats, whereas the acute exposition to this piperidine exerted an anxiolytic effect in the male rat. In both effects, the mechanism of action remains to be characterized.
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