期刊
AGING-US
卷 13, 期 6, 页码 7883-7899出版社
IMPACT JOURNALS LLC
关键词
neighborhood environment; social cohesion; epigenetic aging; DNA methylation
资金
- National Institutes of Health [R01D022720, R01DA022720-S1, RC1MH088283, R01MD011728]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development grant [T32HD007168, K99MD012808, R01MD013349]
- NSF Career Award [1845796]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1845796] Funding Source: National Science Foundation
Living in adverse neighborhood environments may accelerate epigenetic aging, while positive neighborhood attributes could buffer these effects.
Living in adverse neighborhood environments has been linked to risk of aging-related diseases and mortality; however, the biological mechanisms explaining this observation remain poorly understood. DNA methylation (DNAm), a proposed mechanism and biomarker of biological aging responsive to environmental stressors, offers promising insight into potential molecular pathways. We examined associations between three neighborhood social environment measures (poverty, quality, and social cohesion) and three epigenetic clocks (Horvath, Hannum, and PhenoAge) using data from the Detroit Neighborhood Health Study (n=158). Using linear regression models, we evaluated associations in the total sample and stratified by sex and social cohesion. Neighborhood quality was associated with accelerated DNAm aging for Horvath age acceleration (beta = 1.8; 95% CI: 0.4, 3.1), Hannum age acceleration (beta = 1.7; 95% CI: 0.4, 3.0), and PhenoAge acceleration (beta = 2.1; 95% CI: 0.4, 3.8). In models stratified on social cohesion, associations of neighborhood poverty and quality with accelerated DNAm aging remained elevated for residents living in neighborhoods with lower social cohesion, but were null for those living in neighborhoods with higher social cohesion. Our study suggests that living in adverse neighborhood environments can speed up epigenetic aging, while positive neighborhood attributes may buffer effects.
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